The match will be played behind closed doors in accordance with advice from the Austrian government.
United progressed to the round of 16 after beating Club Brugge, while LASK saw off AZ Alkmaar to reach this stage.
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Ole Gunnar Solskjaer’s side have been in improved form of late and will be confident of putting themselves in a strong position to reach the last eight in the second leg.
Here’s everything you need to know ahead of kick-off in Linz:
Kick-off is at 5:55pm on Thursday, 12 March.
The game will be broadcast on BT Sport 2.
Subscribers will be able to stream the match online via the BT Sport app or website.
LASK are without suspended duo Petar Filipovic and Philipp Wiesinger. Wing-back Marvin Potzmann is also injured.
United have habitually rotated in Europe under Ole Gunna Solskjaer and he may do the same after beating Man City last time out.
Paul Pogba and Marcus Rashford are injured. Anthony Martial did not travel with the squad to Austria, with Aaron Wan-Bissaka, Diogo Dalot and Jesse Lingard also missing out.
LASK: Schlager, Trauner, Ramsebner, Wostry, Ranftl, Holland, Michorl, Renner, Frieser, Goiginger, Raguz
Man United: Romero, Tuanzebe, Bailly, Maguire, Shaw, McTominay, Fred, Mata, Fernandes, Greenwood, Ighalo
If United go with a strong lineup they should have enough to get a result in Austria. 1-2 at the end of the first leg.