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Jose Mourinho – coming up against his former side – knows that Spurs cannot afford to drop any points as they face an uphill struggle to secure a Champions League spot.
However, they will be boosted by the return of captain Harry Kane, who has recovered from a long injury layoff.
Sharing the full story, not just the headlines
Manchester United, who will also be aided by the return of fellow England international Marcus Rashford, are just three points adrift of fourth-placed Chelsea and will finally get to see Paul Pogba and Bruno Fernandes working in tandem.
Here is everything you need to know:
The match will take place at the Tottenham Hotspur Stadium on Friday 19 June. Kick-off is at 8.15pm.
The match will be broadcast live on Sky Sports Main Event and Sky Sports Premier League following the conclusion of Norwich vs. Southampton.
Dele Alli has been ruled out of the fixture after being handed a one-game ban by the FA. Harry Kane, Moussa Sissoko and Steven Berwijn have all benefited from the layoff, with Jose Mourinho stating that the trio have all now fully recovered from long injury absences.
Meanwhile, United will also receive a major boost in the returns of Marcus Rashford and Paul Pogba.
Tottenham: Lloris, Aurier, Alderweireld, Dier, Davies, Winks, Lo Celso, Sissoko, Bergwijn, Lucas, Kane.
Manchester United: De Gea, Wan-Bissaka, Lindelof, Maguire, Shaw, McTominay, Fernandes, Pogba, Rashford, Martial, James.
Tottenham – 17/10
Draw – 12/5
Manchester United – 6/4