Pep Guardiola’s side are still waiting nervously on the outcome of their appeal against a two-year Champions League ban, with a second-place finish in the league now all but secured.
City have been in impressive form since the restart, thrashing newly crowned champions Liverpool and advancing to the FA Cup semi-finals.
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Southampton are in a fine vein of form, too, having defeated relegation strugglers Norwich and Watford to climb to within reach of the top half of the table.
Here is everything you need to know:
The match will begin at 7pm at St Mary’s on Sunday 5 July.
The match will be shown live on BBC One and will be available via BBC Sport and the BBC iPlayer, with coverage beginning at 6.35pm.
Sofiane Boufal is expected to remain absent with a thigh injury while Pierre-Emile Hojbjerg is also a doubt after sustaining an ankle injury against Arsenal. Jannik Vestergaard’s inclusion is also in doubt. Jack Stephens and Moussa Djenepo are both available again, though, after completing their suspensions.
Sergio Aguero remains sidelined, while Leroy Sane has now completed his move to Bayern Munich. However, Fernandinho is set to return from a one-match suspension.
Southampton: McCarthy; Walker-Peters, Bednarek, Stephens, Bertrand; Armstrong, Ward-Prowse, Romeu, Redmond; Ings, Long
Manchester City: Ederson; Cancelo, Laporte, Fernandinho, Zinchenko; Rodri, De Bruyne, Foden; Mahrez, Jesus, Sterling
Southampton – 8/1
Draw – 4/1
Man City – 1/3
City have proved that they still have the hunger and desire required to summon their best form, despite there being little to fight for in the league anymore. That quality should shine through against a Southampton side who’ve impressed against smaller sides since the restart, but rolled over rather easily when faced by Arsenal. A routine win for Guardiola’s side feels a likely outcome.
Southampton 0-3 Man City