The dismissal of Nigel Pearson has created uncertainty heading into the game.
But Hayden Mullins, in temporary charge here, will be desperate to take something against Pep Guardiola’s side, for fear of giving Aston Villa or Bournemouth any hope.
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The Citizens are still smarting after being upset by Arsenal in the FA Cup semi-final last weekend, which ended hopes of a famous cup treble, so despite relatively little to play for, they will be intent on regaining some form before the Champions League resumes.
Here are the predicted line-ups and team news for the game at Vicarage Road.
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The match kicks off at 18:00, Tuesday 21 June at Vicarage Road.
The game will be available to watch live on Sky One, Sky Sports Premier League, Sky Sports Main Event, Sky Sports Ultra HD and Pick. Coverage starts at 17:30.
If you’re not a Sky customer you can grab a NOWTV Day Pass here to watch without a subscription.
Gerard Deulofeu (knee), Isaac Success (Achilles) and Daryl Janmaat (knee) are all out. Deeney has had knee problems for a while, but he will likely play through the pain here.
Oleksandr Zinchenko, Joao Cancelo, John Stones and Nicolas Otamendi could all be set for run-outs if Guardiola rotates his squad, with Kyle Walker, Benjamin Mendy and Aymeric Laporte due a rest. While Gabriel Jesus could be handed a breather too, having started six games in a row in all competitions.
Watford XI: Foster; Mariappa, Kabasele, Dawson, Femenia; Hughes, Chalobah; Sarr, Doucoure, Welbeck; Deeney
Man City XI: Ederson; Walker, Stones, Laporte, Zinchenko; De Bruyne, Rodri, Silva; Sterling, Bernardo, Foden
The Hornets are in disarray and City will be fuelled by the hurt of losing the FA Cup semi-final last weekend, it has to be an away win here and more uncertainty at Vicarage Road heading into the final round of fixtures this weekend. 1-3.