The Reds were confirmed as champions nearly a month ago and will receive their silverware after their final home match of the season.
Chelsea are in a great position to secure a top-four finish and Champions League football, but still need one win from their last two matches to do so.
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They beat Manchester United in the FA Cup semi-final at the weekend, so it could be a fantastic end to the season for Frank Lampard and his side.
Here’s all you need to know ahead of the match.
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The match kicks off at 8:15pm on Wednesday, 22 July at Anfield.
The game will be available to watch live on Sky One, Sky Sports Premier League, Sky Sports Main Event, Sky Sports Ultra HD and Pick.
If you’re not a Sky customer you can grab a NOWTV Day Pass here to watch without a subscription.
Liverpool are without captain Jordan Henderson and centre-back Joel Matip. James Milner should recover from a knock, as should Dejan Lovren. Xherdan Shaqiri returned to play a late cameo role in the last game.
Chelsea may rotate after their FA Cup semi-final win at the weekend saw them revert to 3-4-3. Fikayo Tomori and Billy Gilmour are injured, while N’Golo Kante is a doubt.
Liverpool: Alisson; Alexander-Arnold, Gomez, Van Dijk, Robertson; Fabinho, Keita, Wijnaldum; Salah, Firmino, Mane.
Chelsea: Kepta; Azpilicueta, Zouma, Rudiger; James, Jorginho, Kovacic, Alonso; Willian, Giroud, Pulisic.
Much depends on the two teams’ mentalities and ability to avoid errors, as the Reds will want a party after a victory but Chelsea have more to play for on the day.
Liverpool 2-1 Chelsea