Champions League football has driven both sides over 37 games so far, with the Foxes a point outside and requiring victory.
That could mean Ole Gunnar Solskjaer’s side drop out, though eyes will also be on Chelsea hosting Wolves.
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If the Blues take a point, then this game will be a straight shoot-out for the final place.
Here are the predicted line-ups and team news for the game at the King Power.
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When is it and what time is kick-off?
The match will begin at 4pm on Sunday 26 July at the King Power Stadium.
How can I watch it online and on TV?
The match will be broadcast live on Sky Sports Main Event and Sky Sports Ultra HD.
If you’re not a Sky customer you can grab a NOWTV Day Pass here to watch without a subscription.
What is the team news?
James Maddison (hip), Ricardo Pereira (knee), Ben Chilwell (foot), Christian Fuchs (groin) and Caglar Soyuncu (suspended) are all set to miss the decisive game to decide who finishes in the top four, while Marc Albrighton (knock) could return.
Luke Shaw (ankle) and Eric Bailly (concussion) will be monitored ahead of the game, while Axel Tuanzebe and Phil Jones remain sidelined.
Leicester XI: Schmeichel, Justin, Morgan, Evans, Albrighton, Ndidi, Tielemans, Thomas, Perez, Vardy, Barnes
United XI: De Gea, Wan-Bissaka, Lindelof, Maguire, Williams, Pogba, Matic, Greenwood, Fernandes, Rashford, Martial
What are the odds?
United could be caught in two minds here, with a draw enough for them to secure what they crave most – but Ole Gunnar Solskjaer maintains his side will go for the win. Leicester will throw everything at the Red Devils though, and we think with the game in the balance late on, that might play into United’s hands, who should be able to counter to claim victory. 1-2.