In the first leg in March, United were 5-0 victors courtesy of strikes from Odion Ighalo, Dan James, Juan Mata, Mason Greenwood and Andreas Pereira.
It would take somewhat of a miracle for LASK to erase the deficit and earn a quarter-final place, but Solskjaer will still demand that his team to put in a strong performance and keep momentum in the tournament.
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Here’s all you need to know about the game:
When is it and what time is kick-off?
The match will begin at 8pm BST on Wednesday 5 August at Old Trafford.
How can I watch it online and on TV?
The game will be broadcast live on BT Sport 1, BT Sport Extra 1 and BT Sport Ultimate.
Subscribers can also stream the match on the BT Sport website and app.
United have added Teden Mengi and Ethan Laird to their Europa League squad and removed Luke Shaw and Axel Tuanzebe, with the latter pair suffering from injuries.
Chris Smalling, Dean Henderson and Marcos Rojo are unable to be registered for the competition, with their loans having just ended.
Manchester United: Romero; Dalot, Bailly, Lindelof, Williams; McTominay, Fred; James, Mata, Lingard; Ighalo
LASK: Schlager; Wiesinger, Trauner, Andrade; Ranftl, Holland, Michorl, Renner; Tetteh, Frieser; Klauss
United have all but wrapped up this tie already, but Solskjaer will be keen for his players to come away with momentum. The Red Devils won’t press as firmly on the gas as they did in the first leg, but they will still ease past LASK again. Manchester United 3-0 LASK.