In one of the ties of the round, Inter Milan take on Bayer Leverkusen for a place in the Europa League semi-finals.
Antonio Conte will look to put a terbulent few weeks behind him, with the Italian publicly voicing his discontent at the club, sparking speculation he could leave.
There will be no shortage of talent on display here; from Romelu Lukaku to Kai Havertz and Moussa Diaby to Lautaro Martinez.
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The winner will be highly fancied to go all the way in Germany.
Here is how you can watch the game live on television or through a live stream.
When is it and what time is kick-off?
The match will begin at 8pm BST on Monday 10 August at the Esprit Arena, in Dusseldorf, Germany.
How can I watch it online and on TV?
The game will be broadcast live on BT Sport 2. Coverage starts at 19:45.
Subscribers can also stream the match on the BT Sport website and app.
Inter XI: Handanovic; Godin, De Vrij, Bastoni; D’Ambrosio, Barella, Brozovic, Gagliardini, Young; Lukaku, Lautaro Martinez
Leverkusen XI: Hradecky; Wendell, S. Bender, Tah, L. Bender; Baumgartlinger, Dermibay, Palacios; Diaby, Volland, Havertz
Inter Milan 21/20
Bayer Leverkusen 13/5