Hansi Flick’s side have been dominant all year and hit Barcelona for eight with a devastating display of attacking football.
Lyon will likely remain calm though, having already coped with Juventus and Manchester City as underdogs and the French side possess the tools to put up more resistance than the Catalans.
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Robert Lewandowski continues to dominate in front of goal and will look to score in a ninth successive Champions League match – a feat only matched by Ruud Van Nistelrooy in 2003 (nine) and Cristiano Ronaldo in 2018 (11).
Here is our prediction for the game at the Estádio José Alvalade.
When is it and what time is kick-off?
The match will begin at 8pm BST on Wednesday 19 August at the Estádio Jose Alvalade in Lisbon.
How can I watch it online and on TV?
The game will be broadcast live on BT Sport 1 and BT Sport Extra 1, as well as BT Sport Ultimate – coverage begins at 7pm.
Subscribers can also stream the match on the BT Sport website and app.
Moussa Dembele’s double off the bench will give Rudi Garcia a decision to make over whether to retain Karl Toko Ekambi alongside Memphis Depay, otherwise it’ll be an unchanged side.
The only real doubt for Bayern is whether Benjamin Pavard has proven his fitness enough to be considered at right-back after returning to light training on Monday, which would send Joshua Kimmich into midfield, likely in place of Leon Goretzka.
Lyon XI: Lopes; Marcelo, Denayer, Marcal; Dubois, Caqueret, Guimaraes, Aouar, Cornet; Ekambi, Memphis
Bayern Munich XI: Neuer; Kimmich, Boateng, Alaba, Davies; Goretzka, Thiago; Gnabry, Muller, Coman; Lewandowski
Bayern Munich: 1/5
Can lightning strike three times? Lyon upset Juventus and Manchester City, but Bayern are a different animal, while it’s incredible to think a third big upset would only grant them a place in the final in what has been one of the toughest runs seen in the Champions League knock-out stages in recent years. Bayern have too much quality to conceive of another upset here and too many options to change it should they find themselves in a hole early on. We’re going for a comfortable Bayern 3-1 win.